Activity Details

Accredited By

Rush University Medical Center

Co-Provided By

Target Audience

This activity is designed to meet the educational needs of community oncologists, hematologists, hematologists/oncologists, oncology nurses, NPs, pharmacists, and other healthcare professionals involved in the treatment of patients with Waldenström’s Macroglobulinemia.

Learning Objectives

After completing this program, participants should be able to:

• Discuss the criteria for diagnosis and initiation of therapy for patients with Waldenström’s Macroglobulinemia, and use this information to guide initial workup and treatment decision-making
• Assess the safety and efficacy of practice-changing clinical trial findings of current and emerging agents for Waldenström’s Macroglobulinemia
• Integrate current guidelines, available clinical trial data, and real-world findings into individualized strategies for treatment selection, sequencing, and monitoring of Waldenström’s Macroglobulinemia

Activity Description

This education activity is designed to provide the healthcare team with the latest developments and critical insights into treating their patients with Waldenström’s Macroglobulinemia. This education will support the healthcare professional in his/her practice setting with the essential tools to critically evaluate efficacy, safety, clinical effectiveness, and application.

Statement of Educational Need

The treatment of Waldenström’s Macroglobulinemia (WM) patients should be highly personalized, and the patient’s clinical presentation, comorbidities, genomic profile, and preferences, as well as toxicity of the treatment regimens, should be taken into account. Considering the continued evolution of therapeutic modalities and management strategies for WM and the information burden placed on busy community healthcare professionals who may have little to no experience with WM, expert guidance and interpretation of the clinical significance of emerging clinical data would benefit those caring for patients with WM, allowing for ease of assessment and incorporation into clinical practice.

Faculty

Steven P. Treon, MD, MA, PhD
Professor of Medicine, Harvard Medical School
Director, Bing Center for Waldenström’s Macroglobulinemia
Dana Farber Cancer Center
Boston, MA

Dr. Treon has provided the following disclosure information:

• Research Support/P.I.: AbbVie/Pharmacyclics, Beigene, BMS, Eli Lilly
• Consultant: Janssen, AbbVie/Pharmacyclics, Beigene, BMS

Accreditation Statement

In support of improving patient care, Rush University Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician/Physician Assistant/Nurse Practitioner
Rush University Medical Center designates this enduring activity for a maximum of one (1.0) AMA PRA Category 1 Credit(s)™. Physicians/Physician Assistants/Nurse Practitioners should claim only credit commensurate with the extent of their participation in the activity.

Nurse
Rush University Medical Center designates this enduring activity for a maximum of one (1.0) nursing contact hour(s).

This activity will fulfill Category 2 contact hour requirements for pharmacology for ANCC-certified advanced practice nurses.

Pharmacist
Rush University Medical Center designates this knowledge-based enduring activity for a maximum of one (1.0) contact hour(s) for pharmacists.

Proof of participation will be posted to your NABP CPE profile within 4 to 6 weeks for participants who have successfully completed the post-test. Participants must participate in the entire presentation and complete the course evaluation to receive continuing pharmacy education credit.

Instructions for Receiving Credit

In order to receive credit for participating in this program, participants must listen to the program in its entirety and then complete and submit the CE evaluation form at the conclusion of the program.

Statement of Commercial Support

This activity is supported by an educational grant from Ascentage Pharma Group, Pharmacyclics LLC, an AbbVie Company, and Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC.

Disclaimer Statement/Disclosure of Unlabeled Use

Rush University Medical Center and PleXus Communications ensure balance, independence, objectivity, and scientific rigor in all our educational activities. In accordance with this policy, Rush University Medical Center identifies conflicts of interest with its instructors, content managers, and other individuals who are in a position to control the content of an activity. Conflicts are resolved by Rush University Medical Center to ensure that all scientific research referred to, reported, or used in a continuing education activity conforms to the generally accepted standards of experimental design, data collection, and analysis. Rush University Medical Center is committed to providing its learners with high-quality activities that promote improvements or quality in healthcare and not the business interest of a commercial interest.

Contact Information for Questions About the Activity

info@plexuscomm.com

Activity Details

Accredited By

Rush University Medical Center

Co-Provided By

Target Audience

This activity is designed to meet the educational needs of community oncologists, hematologists, hematologists/oncologists, oncology nurses, NPs, pharmacists, and other healthcare professionals involved in the treatment of patients with Waldenström’s Macroglobulinemia.

Learning Objectives

After completing this program, participants should be able to:

• Discuss the criteria for diagnosis and initiation of therapy for patients with Waldenström’s Macroglobulinemia, and use this information to guide initial workup and treatment decision-making
• Assess the safety and efficacy of practice-changing clinical trial findings of current and emerging agents for Waldenström’s Macroglobulinemia
• Integrate current guidelines, available clinical trial data, and real-world findings into individualized strategies for treatment selection, sequencing, and monitoring of Waldenström’s Macroglobulinemia

Activity Description

This education activity is designed to provide the healthcare team with the latest developments and critical insights into treating their patients with Waldenström’s Macroglobulinemia. This education will support the healthcare professional in his/her practice setting with the essential tools to critically evaluate efficacy, safety, clinical effectiveness, and application.

Statement of Educational Need

The treatment of Waldenström’s Macroglobulinemia (WM) patients should be highly personalized, and the patient’s clinical presentation, comorbidities, genomic profile, and preferences, as well as toxicity of the treatment regimens, should be taken into account. Considering the continued evolution of therapeutic modalities and management strategies for WM and the information burden placed on busy community healthcare professionals who may have little to no experience with WM, expert guidance and interpretation of the clinical significance of emerging clinical data would benefit those caring for patients with WM, allowing for ease of assessment and incorporation into clinical practice.

Faculty

Steven P. Treon, MD, MA, PhD
Professor of Medicine, Harvard Medical School
Director, Bing Center for Waldenström’s Macroglobulinemia
Dana Farber Cancer Center
Boston, MA

Dr. Treon has provided the following disclosure information:

• Research Support/P.I.: AbbVie/Pharmacyclics, Beigene, BMS, Eli Lilly
• Consultant: Janssen, AbbVie/Pharmacyclics, Beigene, BMS

Accreditation Statement

In support of improving patient care, Rush University Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician/Physician Assistant/Nurse Practitioner
Rush University Medical Center designates this enduring activity for a maximum of one (1.0) AMA PRA Category 1 Credit(s)™. Physicians/Physician Assistants/Nurse Practitioners should claim only credit commensurate with the extent of their participation in the activity.

Nurse
Rush University Medical Center designates this enduring activity for a maximum of one (1.0) nursing contact hour(s).

This activity will fulfill Category 2 contact hour requirements for pharmacology for ANCC-certified advanced practice nurses.

Pharmacist
Rush University Medical Center designates this knowledge-based enduring activity for a maximum of one (1.0) contact hour(s) for pharmacists.

Proof of participation will be posted to your NABP CPE profile within 4 to 6 weeks for participants who have successfully completed the post-test. Participants must participate in the entire presentation and complete the course evaluation to receive continuing pharmacy education credit.

Instructions for Receiving Credit

In order to receive credit for participating in this program, participants must listen to the program in its entirety and then complete and submit the CE evaluation form at the conclusion of the program.

Statement of Commercial Support

This activity is supported by an educational grant from Ascentage Pharma Group, Pharmacyclics LLC, an AbbVie Company, and Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC.

Disclaimer Statement/Disclosure of Unlabeled Use

Rush University Medical Center and PleXus Communications ensure balance, independence, objectivity, and scientific rigor in all our educational activities. In accordance with this policy, Rush University Medical Center identifies conflicts of interest with its instructors, content managers, and other individuals who are in a position to control the content of an activity. Conflicts are resolved by Rush University Medical Center to ensure that all scientific research referred to, reported, or used in a continuing education activity conforms to the generally accepted standards of experimental design, data collection, and analysis. Rush University Medical Center is committed to providing its learners with high-quality activities that promote improvements or quality in healthcare and not the business interest of a commercial interest.

Contact Information for Questions About the Activity

info@plexuscomm.com

Activity Details

Accredited By

The University of Nebraska Medical Center

Target Audience

The target audience for this activity is community and academic medical oncologists, hematologists, hematologic oncologists, advanced practitioners (NP/PA/PharmD), and other clinicians who treat patients with CLL.

Learning Objectives

After participating in this activity, participants should be better able to:

• Identify various disease- and patient-related factors that impact the selection of BTK inhibitor use in patients with CLL
• Evaluate clinical trial data of BTK inhibitors that are currently approved for the treatment of patients with CLL
• Assess trial results of investigational BTK-based approaches to the treatment of CLL, including monotherapy and combination approaches
• Review strategies for improving patient outcomes, including optimal selection and sequencing of therapy, adverse event management, as well as oral adherence strategies

Activity Description

This webcast will provide expert guidance on how to correctly use current and emerging BTK inhibitors safely and effectively for patients with CLL and plan strategies for optimal integration of these novel agents into practice.

Statement of Educational Need

Major advances in the diagnosis and treatment of CLL have occurred in the past decade. In the future, studies will continue to BTK inhibitors have substantially altered the management, clinical course, and outcome of patients with CLL. This is especially true for patients with previously limited treatment options due to disease characteristics or coexisting diseases. Significant efforts are underway to investigate the optimal combinations, timing, and sequencing of BTK inhibitors with other regimens and targeted agents, and to capitalize on the immunomodulatory modes of action of BTK inhibitors to correct tumor-induced immune defects and to achieve long-lasting tumor control.

Agenda

• Welcome & Introductions
• Rationale for Targeting Bruton Tyrosine Kinase (BTK) in Patients With CLL
• Currently Available BTK Inhibitor-Based Strategies: Phase 3 Studies
• Future Directions and Emerging Data of BTK Inhibitor Therapy
• Considerations for Improving Patient Outcomes
• Conclusions

Faculty and Planning Committee Disclosures

As a jointly accredited provider, the University of Nebraska Medical Center (UNMC) ensures accuracy, balance, objectivity, independence, and scientific rigor in its educational activities and is committed to protecting learners from promotion, marketing, and commercial bias. All faculty, planners, and others in a position to control continuing education content participating in an accredited continuing education activity are required to disclose all financial relationships with ineligible companies. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. The accredited provider is responsible for mitigating all relevant financial relationships in accredited continuing education. Disclosure of these commitments and/or relationships is included in these activity materials so that participants may formulate their own judgments in interpreting its content and evaluating its recommendations.

This activity may include presentations in which faculty may discuss off-label and/or investigational use of pharmaceuticals or instruments not yet FDA-approved. Participants should note that the use of products outside currently FDA-approved labeling should be considered experimental and are advised to consult current prescribing information for FDA-approved indications. All materials are included with the permission of the faculty. The opinions expressed are those of the faculty and are not to be construed as those of UNMC.

The accredited provider has mitigated and is disclosing identified relevant financial relationships for the following faculty, planners, and others in control of content prior to assuming their roles.

All faculty and planning committee members have no conflicts to disclose with the exception of the following:

Moderator
Matthew S. Davids, MD, MMSc
Associate Professor of Medicine
Harvard Medical School
Director of Clinical Research, Division of Lymphoma
Dana-Farber Cancer Institute
Boston, Massachusetts

Disclosures
Contracted Research & Publishing: AbbVie Inc., Ascentage Pharma, AstraZeneca, Genentech, MEI Pharma Inc., Pharmacyclics LLC, Surface Oncology, TG Therapeutics, Verastem, Inc.

Consulting Fees: AbbVie Inc., Adaptive Biotechnologies, Ascentage Pharma, AstraZeneca, BeiGene, Celgene Corporation, Genentech, Janssen, MEI Pharma Inc., Pharmacyclics LLC, Research To Practice, TG Therapeutics, Verastem, Inc.

Planning Committee
The following planning committee members have nothing to disclose:
UNMC: Brenda Ram, CMP, CHCP
Bio Ascend: Patti Bunyasaranand, MS; Dru Dace, PhD; Kraig Steubing

Continuing Education

In support of improving patient care, this activity has been planned and implemented by the University of Nebraska Medical Center and Bio Ascend. The University of Nebraska Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

The University of Nebraska Medical Center designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Instructions for Receiving Credit

There are no fees for participating in and receiving continuing education credit for this activity. During the accredited period, participants must: 1) read the educational objectives and conflict of interest disclosures; 2) study the educational activity; 3) complete the pre- and post-test and evaluation.

Participants who complete the educational activity, pre- and post-test, and evaluation will receive an accredited continuing education credit certificate.

Statement of Commercial Support

Educational grant support provided by BeiGene, Ltd. and Pharmacyclics LLC.

Disclaimer Statement/Disclosure of Unlabeled Use

UNMC and Bio Ascend do not recommend the use of any agent outside of the labeled indication. The opinions expressed in the educational activity do not necessarily represent the views of UNMC and Bio Ascend.

Contact Information for Questions About the Activity

info@bioascend.com

Activity Details

Accredited By

The University of Nebraska Medical Center

Target Audience

The target audience for this activity is community and academic medical oncologists, hematologists, hematologic oncologists, advanced practitioners (NP/PA/PharmD), and other clinicians who treat patients with CLL.

Learning Objectives

After participating in this activity, participants should be better able to:

• Identify various disease- and patient-related factors that impact the selection of BTK inhibitor use in patients with CLL
• Evaluate clinical trial data of BTK inhibitors that are currently approved for the treatment of patients with CLL
• Assess trial results of investigational BTK-based approaches to the treatment of CLL, including monotherapy and combination approaches
• Review strategies for improving patient outcomes, including optimal selection and sequencing of therapy, adverse event management, as well as oral adherence strategies

Activity Description

This webcast will provide expert guidance on how to correctly use current and emerging BTK inhibitors safely and effectively for patients with CLL and plan strategies for optimal integration of these novel agents into practice.

Statement of Educational Need

Major advances in the diagnosis and treatment of CLL have occurred in the past decade. In the future, studies will continue to BTK inhibitors have substantially altered the management, clinical course, and outcome of patients with CLL. This is especially true for patients with previously limited treatment options due to disease characteristics or coexisting diseases. Significant efforts are underway to investigate the optimal combinations, timing, and sequencing of BTK inhibitors with other regimens and targeted agents, and to capitalize on the immunomodulatory modes of action of BTK inhibitors to correct tumor-induced immune defects and to achieve long-lasting tumor control.

Agenda

• Welcome & Introductions
• Rationale for Targeting Bruton Tyrosine Kinase (BTK) in Patients With CLL
• Currently Available BTK Inhibitor-Based Strategies: Phase 3 Studies
• Future Directions and Emerging Data of BTK Inhibitor Therapy
• Considerations for Improving Patient Outcomes
• Conclusions

Faculty and Planning Committee Disclosures

As a jointly accredited provider, the University of Nebraska Medical Center (UNMC) ensures accuracy, balance, objectivity, independence, and scientific rigor in its educational activities and is committed to protecting learners from promotion, marketing, and commercial bias. All faculty, planners, and others in a position to control continuing education content participating in an accredited continuing education activity are required to disclose all financial relationships with ineligible companies. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. The accredited provider is responsible for mitigating all relevant financial relationships in accredited continuing education. Disclosure of these commitments and/or relationships is included in these activity materials so that participants may formulate their own judgments in interpreting its content and evaluating its recommendations.

This activity may include presentations in which faculty may discuss off-label and/or investigational use of pharmaceuticals or instruments not yet FDA-approved. Participants should note that the use of products outside currently FDA-approved labeling should be considered experimental and are advised to consult current prescribing information for FDA-approved indications. All materials are included with the permission of the faculty. The opinions expressed are those of the faculty and are not to be construed as those of UNMC.

The accredited provider has mitigated and is disclosing identified relevant financial relationships for the following faculty, planners, and others in control of content prior to assuming their roles.

All faculty and planning committee members have no conflicts to disclose with the exception of the following:

Moderator
Matthew S. Davids, MD, MMSc
Associate Professor of Medicine
Harvard Medical School
Director of Clinical Research, Division of Lymphoma
Dana-Farber Cancer Institute
Boston, Massachusetts

Disclosures
Contracted Research & Publishing: AbbVie Inc., Ascentage Pharma, AstraZeneca, Genentech, MEI Pharma Inc., Pharmacyclics LLC, Surface Oncology, TG Therapeutics, Verastem, Inc.

Consulting Fees: AbbVie Inc., Adaptive Biotechnologies, Ascentage Pharma, AstraZeneca, BeiGene, Celgene Corporation, Genentech, Janssen, MEI Pharma Inc., Pharmacyclics LLC, Research To Practice, TG Therapeutics, Verastem, Inc.

Planning Committee
The following planning committee members have nothing to disclose:
UNMC: Brenda Ram, CMP, CHCP
Bio Ascend: Patti Bunyasaranand, MS; Dru Dace, PhD; Kraig Steubing

Continuing Education

In support of improving patient care, this activity has been planned and implemented by the University of Nebraska Medical Center and Bio Ascend. The University of Nebraska Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

The University of Nebraska Medical Center designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Instructions for Receiving Credit

There are no fees for participating in and receiving continuing education credit for this activity. During the accredited period, participants must: 1) read the educational objectives and conflict of interest disclosures; 2) study the educational activity; 3) complete the pre- and post-test and evaluation.

Participants who complete the educational activity, pre- and post-test, and evaluation will receive an accredited continuing education credit certificate.

Statement of Commercial Support

Educational grant support provided by BeiGene, Ltd. and Pharmacyclics LLC.

Disclaimer Statement/Disclosure of Unlabeled Use

UNMC and Bio Ascend do not recommend the use of any agent outside of the labeled indication. The opinions expressed in the educational activity do not necessarily represent the views of UNMC and Bio Ascend.

Contact Information for Questions About the Activity

info@bioascend.com

Activity Details

Provider Statement

This CME activity for ACCME credit is provided by Integrity Continuing Education, Inc.

This CE activity for ANCC credit is jointly provided by Global Education Group and Integrity Continuing Education, Inc.

Statement of Commercial Support

Supported by an educational grant from Takeda Pharmaceuticals U.S.A., Inc.

Target Audience

This educational activity has been designed to meet the needs of hematologist/oncologists, medical oncologists, physician assistants, nurse practitioners, and advanced practice nurses who treat and manage patients with multiple myeloma.

Program Overview

Evidence has demonstrated that undertreatment of fit elderly multiple myeloma (MM) patients occurs more frequently than overtreatment. While overtreatment of frail MM patients can induce unnecessary morbidity and mortality, an appropriate assessment for frailty is key to determine whether the patient is actually frail or in fact fit. This step ensures optimal outcomes and improved health-related quality of life.

This In The Clinic activity features a discussion on proper assessment of older MM patients, different scoring systems, the role of real-world evidence (RWE), and trials that support the use of RWE. The clinical case scenarios will allow participants to utilize information from the discussions. A simplified, downloadable frailty scoring tool is also included.

Learning Objectives

• ASSESS patients for fitness/frailty to select appropriate treatment based on individual results
• EVALUATE patient data, including real-world data such as patient reported outcomes and assessment scores, to determine the most appropriate treatment regimens
• IDENTIFY strategies for managing toxicities and comorbidities associated with MM in older patients

Moderator

Rafael Fonseca, MD
Chief Innovation Officer
Getz Family Professor of Cancer
Department of Hematology/Oncology
Distinguished Mayo Clinic Investigator
Phoenix, Arizona

Faculty Presenters

Faith Davies, MBBCh, MRCP, MD, FRCPath
Professor of Medicine
Director, Myeloma Clinical Program
Perlmutter Cancer Center
NYU Langone Health
New York, New York

Robert Orlowski, MD, PhD
Florence Maude Thomas Cancer Research Professor
Professor, Department of Experimental Therapeutics
Director, Myeloma Section
The University of Texas
MD Anderson Cancer Center
Houston, Texas

Case Study Development

Disclosure of Conflicts of Interest

Integrity Continuing Education, Inc. and Global Education Group require instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Faith Davies, MBBCh, MRCP, MD, FRCPath
Consultant: AbbVie, Amgen, Bristol Myers Squibb/Celgene, GlaxoSmithKline, Janssen, Oncopeptides, Sanofi, Takeda

Rafael Fonseca, MD
Consultant: AbbVie, Aduro, Amgen, Bayer, Bristol Myers Squibb, Celgene, GlaxoSmithKline, Janssen, Juno, Kite, Merck, Novartis, OncoTracker, Pharmacyclics, Sanofi, Takeda
Scientific Advisory Boards: Adaptive Biotechnologies, OncoTracker

Hira Mian, MD
Research Funding: Janssen
Advisor/Speaker: Amgen, Bristol Myers Squibb, GlaxoSmithKline, Janssen, Sanofi, Takeda

Robert Orlowski, MD, PhD
Consultant: AbbVie, Bristol Myers Squibb, GlaxoSmithKline Biologicals, Karyopharm Therapeutics, Inc., Meridian Therapeutics, Monte Rosa Therapeutics, Neoleukin Corporation, Oncopeptides AB, Regeneron Pharmaceuticals, Inc.

The following project managers/planners: Lindsay Borvansky, Ashley Cann, Samuel Ciociola, Donna Fausak, Andrea Funk, Liddy Knight, David Lemler, PhD, and Rhys Williams, RN, MSN, FNP, reported that they or their spouses/life partners have no financial relationships or relationships to products or devices with ineligible companies related to the content of this CE activity.

Physician Continuing Education

Accreditation Statement
Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation
Integrity Continuing Education, Inc. designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Continuing Education

Global Education Group is accredited with distinction as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

This educational activity for 1.0 contact hour(s) is provided by Global Education Group. Nurses should claim only the credit commensurate with the extent of their participation in the activity.

Instructions for Receiving Credit

There are no fees for participating and receiving CE/CME credit for this activity. During the period of February 28, 2022, through February 28, 2023, participants must:

• Read the learning objectives and faculty disclosures
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 70% or better.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. and Global Education Group do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Contact Information for Questions About the Activity

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

For information about ANCC accreditation of this activity, please contact Global Education Group at (303) 395-1782 or cme@globaleducationgroup.com.

Disclaimer

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Activity Details

Provider Statement

This CME activity for ACCME credit is provided by Integrity Continuing Education, Inc.

This CE activity for ANCC credit is jointly provided by Global Education Group and Integrity Continuing Education, Inc.

Statement of Commercial Support

Supported by an educational grant from Takeda Pharmaceuticals U.S.A., Inc.

Target Audience

This educational activity has been designed to meet the needs of hematologist/oncologists, medical oncologists, physician assistants, nurse practitioners, and advanced practice nurses who treat and manage patients with multiple myeloma.

Program Overview

Evidence has demonstrated that undertreatment of fit elderly multiple myeloma (MM) patients occurs more frequently than overtreatment. While overtreatment of frail MM patients can induce unnecessary morbidity and mortality, an appropriate assessment for frailty is key to determine whether the patient is actually frail or in fact fit. This step ensures optimal outcomes and improved health-related quality of life.

This In The Clinic activity features a discussion on proper assessment of older MM patients, different scoring systems, the role of real-world evidence (RWE), and trials that support the use of RWE. The clinical case scenarios will allow participants to utilize information from the discussions. A simplified, downloadable frailty scoring tool is also included.

Learning Objectives

• ASSESS patients for fitness/frailty to select appropriate treatment based on individual results
• EVALUATE patient data, including real-world data such as patient reported outcomes and assessment scores, to determine the most appropriate treatment regimens
• IDENTIFY strategies for managing toxicities and comorbidities associated with MM in older patients

Moderator

Rafael Fonseca, MD
Chief Innovation Officer
Getz Family Professor of Cancer
Department of Hematology/Oncology
Distinguished Mayo Clinic Investigator
Phoenix, Arizona

Faculty Presenters

Faith Davies, MBBCh, MRCP, MD, FRCPath
Professor of Medicine
Director, Myeloma Clinical Program
Perlmutter Cancer Center
NYU Langone Health
New York, New York

Robert Orlowski, MD, PhD
Florence Maude Thomas Cancer Research Professor
Professor, Department of Experimental Therapeutics
Director, Myeloma Section
The University of Texas
MD Anderson Cancer Center
Houston, Texas

Case Study Development

Disclosure of Conflicts of Interest

Integrity Continuing Education, Inc. and Global Education Group require instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Faith Davies, MBBCh, MRCP, MD, FRCPath
Consultant: AbbVie, Amgen, Bristol Myers Squibb/Celgene, GlaxoSmithKline, Janssen, Oncopeptides, Sanofi, Takeda

Rafael Fonseca, MD
Consultant: AbbVie, Aduro, Amgen, Bayer, Bristol Myers Squibb, Celgene, GlaxoSmithKline, Janssen, Juno, Kite, Merck, Novartis, OncoTracker, Pharmacyclics, Sanofi, Takeda
Scientific Advisory Boards: Adaptive Biotechnologies, OncoTracker

Hira Mian, MD
Research Funding: Janssen
Advisor/Speaker: Amgen, Bristol Myers Squibb, GlaxoSmithKline, Janssen, Sanofi, Takeda

Robert Orlowski, MD, PhD
Consultant: AbbVie, Bristol Myers Squibb, GlaxoSmithKline Biologicals, Karyopharm Therapeutics, Inc., Meridian Therapeutics, Monte Rosa Therapeutics, Neoleukin Corporation, Oncopeptides AB, Regeneron Pharmaceuticals, Inc.

The following project managers/planners: Lindsay Borvansky, Ashley Cann, Samuel Ciociola, Donna Fausak, Andrea Funk, Liddy Knight, David Lemler, PhD, and Rhys Williams, RN, MSN, FNP, reported that they or their spouses/life partners have no financial relationships or relationships to products or devices with ineligible companies related to the content of this CE activity.

Physician Continuing Education

Accreditation Statement
Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation
Integrity Continuing Education, Inc. designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Continuing Education

Global Education Group is accredited with distinction as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

This educational activity for 1.0 contact hour(s) is provided by Global Education Group. Nurses should claim only the credit commensurate with the extent of their participation in the activity.

Instructions for Receiving Credit

There are no fees for participating and receiving CE/CME credit for this activity. During the period of February 28, 2022, through February 28, 2023, participants must:

• Read the learning objectives and faculty disclosures
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 70% or better.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. and Global Education Group do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Contact Information for Questions About the Activity

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

For information about ANCC accreditation of this activity, please contact Global Education Group at (303) 395-1782 or cme@globaleducationgroup.com.

Disclaimer

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Activity Details

Accredited By

Rush University Medical Center

Co-Provided By

Target Audience

This activity is designed to meet the educational needs of hematologists/oncologists, community oncologists, oncology nurses and NPs, pharmacists, and other healthcare professionals involved in the treatment of patients with large B-cell lymphoma.

Learning Objectives

After completing this program, participants should be able to:

• Analyze the latest developments in cellular and targeted therapies used for the treatment of LBCL, as well as how these approaches fit into the current treatment landscape
• Assess ongoing clinical trials using cellular and targeted therapies to treat LBCL, including studies focused on using cellular and targeted therapies in the frontline setting
• Outline adverse effects associated with cellular and targeted therapies and describe effective approaches to appropriately manage these effects
• Identify patients with LBCL who are candidates for cellular and targeted therapy and formulate individualized treatment plans based on intrinsic characteristics of the patient, the disease, and the treatment

Activity Description

This educational activity is designed to provide the oncology care team with the latest developments and critical insights into the management of large B-cell lymphoma. This education will support the healthcare professional in his/her practice setting with the essential tools to critically evaluate efficacy, safety, clinical effectiveness, and application.

Statement of Educational Need

To provide optimal patient care, clinicians must be prepared with a comprehensive understanding of the appropriate diagnosis and risk stratification of patients with LBCL and the clinical utility of agents that could significantly impact patient outcomes. With the recent advances in cellular and targeted therapies for LBCL, the use of approved and investigational agents is anticipated to expand over the coming years. Clinicians must be up-to-date on the efficacy and safety profile of currently approved and investigational agents to offer patients the best clinical outcomes.

Faculty

Caron Jacobson, MD
Medical Director, Immune Effector Cell Therapy Program
Senior Physician
Assistant Professor of Medicine, Harvard Medical School
Dana-Farber Cancer Institute
Boston, MA

Dr. Jacobson has provided the following disclosure information:

• Consulting for Kite/Gilead, BMS/Celgene, Novartis, Precision Biosciences, Nkarta, Lonza, bluebird bio, AbbVie, Ipsen
• Research funding from Kite/Gilead, Pfizer

Accreditation Statement

In support of improving patient care, Rush University Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician/Physician Assistant/Nurse Practitioner
Rush University Medical Center designates this enduring activity for a maximum of one (1.0) AMA PRA Category 1 Credit(s)™. Physicians/Physician Assistants/Nurse Practitioners should claim only credit commensurate with the extent of their participation in the activity.

Nurse
Rush University Medical Center designates this enduring activity for a maximum of one (1.0) nursing contact hour(s).

This activity will fulfill Category 2 contact hour requirements for pharmacology for ANCC-certified advanced practice nurses.

Pharmacist
Rush University Medical Center designates this knowledge-based enduring activity for a maximum of one (1.0) contact hour(s) for pharmacists.

Proof of participation will be posted to your NABP CPE profile within 4 to 6 weeks for participants who have successfully completed the post-test. Participants must participate in the entire presentation and complete the course evaluation to receive continuing pharmacy education credit.

Instructions for Receiving Credit

In order to receive credit for participating in this program, participants must listen to the program in its entirety and then complete and submit the CE evaluation form at the conclusion of the program.

Statement of Commercial Support

Supported by an educational grant from ADC Therapeutics Inc., Bristol Myers Squibb, Genentech, Genmab US, Inc., and Incyte who have had no influence on, control of, nor input into the development or performance of the activity.

Disclaimer Statement/Disclosure of Unlabeled Use

Rush University Medical Center and PleXus Communications ensure balance, independence, objectivity, and scientific rigor in all our educational activities. In accordance with this policy, Rush University Medical Center identifies conflicts of interest with its instructors, content managers, and other individuals who are in a position to control the content of an activity. Conflicts are resolved by Rush University Medical Center to ensure that all scientific research referred to, reported, or used in a continuing education activity conforms to the generally accepted standards of experimental design, data collection, and analysis. Rush University Medical Center is committed to providing its learners with high-quality activities that promote improvements or quality in health care and not the business interest of a commercial interest.

Contact Information for Questions About the Activity

info@plexuscomm.com

Activity Details

Accredited By

Rush University Medical Center

Co-Provided By

Target Audience

This activity is designed to meet the educational needs of hematologists/oncologists, community oncologists, oncology nurses and NPs, pharmacists, and other healthcare professionals involved in the treatment of patients with large B-cell lymphoma.

Learning Objectives

After completing this program, participants should be able to:

• Analyze the latest developments in cellular and targeted therapies used for the treatment of LBCL, as well as how these approaches fit into the current treatment landscape
• Assess ongoing clinical trials using cellular and targeted therapies to treat LBCL, including studies focused on using cellular and targeted therapies in the frontline setting
• Outline adverse effects associated with cellular and targeted therapies and describe effective approaches to appropriately manage these effects
• Identify patients with LBCL who are candidates for cellular and targeted therapy and formulate individualized treatment plans based on intrinsic characteristics of the patient, the disease, and the treatment

Activity Description

This educational activity is designed to provide the oncology care team with the latest developments and critical insights into the management of large B-cell lymphoma. This education will support the healthcare professional in his/her practice setting with the essential tools to critically evaluate efficacy, safety, clinical effectiveness, and application.

Statement of Educational Need

To provide optimal patient care, clinicians must be prepared with a comprehensive understanding of the appropriate diagnosis and risk stratification of patients with LBCL and the clinical utility of agents that could significantly impact patient outcomes. With the recent advances in cellular and targeted therapies for LBCL, the use of approved and investigational agents is anticipated to expand over the coming years. Clinicians must be up-to-date on the efficacy and safety profile of currently approved and investigational agents to offer patients the best clinical outcomes.

Faculty

Caron Jacobson, MD
Medical Director, Immune Effector Cell Therapy Program
Senior Physician
Assistant Professor of Medicine, Harvard Medical School
Dana-Farber Cancer Institute
Boston, MA

Dr. Jacobson has provided the following disclosure information:

• Consulting for Kite/Gilead, BMS/Celgene, Novartis, Precision Biosciences, Nkarta, Lonza, bluebird bio, AbbVie, Ipsen
• Research funding from Kite/Gilead, Pfizer

Accreditation Statement

In support of improving patient care, Rush University Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician/Physician Assistant/Nurse Practitioner
Rush University Medical Center designates this enduring activity for a maximum of one (1.0) AMA PRA Category 1 Credit(s)™. Physicians/Physician Assistants/Nurse Practitioners should claim only credit commensurate with the extent of their participation in the activity.

Nurse
Rush University Medical Center designates this enduring activity for a maximum of one (1.0) nursing contact hour(s).

This activity will fulfill Category 2 contact hour requirements for pharmacology for ANCC-certified advanced practice nurses.

Pharmacist
Rush University Medical Center designates this knowledge-based enduring activity for a maximum of one (1.0) contact hour(s) for pharmacists.

Proof of participation will be posted to your NABP CPE profile within 4 to 6 weeks for participants who have successfully completed the post-test. Participants must participate in the entire presentation and complete the course evaluation to receive continuing pharmacy education credit.

Instructions for Receiving Credit

In order to receive credit for participating in this program, participants must listen to the program in its entirety and then complete and submit the CE evaluation form at the conclusion of the program.

Statement of Commercial Support

Supported by an educational grant from ADC Therapeutics Inc., Bristol Myers Squibb, Genentech, Genmab US, Inc., and Incyte who have had no influence on, control of, nor input into the development or performance of the activity.

Disclaimer Statement/Disclosure of Unlabeled Use

Rush University Medical Center and PleXus Communications ensure balance, independence, objectivity, and scientific rigor in all our educational activities. In accordance with this policy, Rush University Medical Center identifies conflicts of interest with its instructors, content managers, and other individuals who are in a position to control the content of an activity. Conflicts are resolved by Rush University Medical Center to ensure that all scientific research referred to, reported, or used in a continuing education activity conforms to the generally accepted standards of experimental design, data collection, and analysis. Rush University Medical Center is committed to providing its learners with high-quality activities that promote improvements or quality in health care and not the business interest of a commercial interest.

Contact Information for Questions About the Activity

info@plexuscomm.com